Publications

    1. AW Tarudji, CC Gee, HA Miller, R Steffen, ET Curtis, AM Priester, AJ Convertine, FM Kievit. Antioxidant Theranostic Copolymer-Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model. Adv Therapeutics, 2023.Adv Therapeutics Cover
    2. MA Schake, IS McCue, ET Curtis, TJ Ripperda, S Harvey, BT Hackfort, A Fitzwater, YS Chatzizisis, FM Kievit, RM Pedrigi. Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization. iScience, 26 (6), 106760, 2023.
    3. CC Gee, R Steffen, FM Kievit. An updated Barnes maze protocol for assessing the outcome of controlled cortical impact mouse models of traumatic brain injury. J Neuroscience Methods, 392, 109866, 2023.
    4. AW Tarudji, HA Miller, ET Curtis, CL Porter, GL Madsen, FM Kievit. Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury. J Control Release, 355, 149-159, 2023.
    5. MF Attia, R Akasov, NM Elbaz, TC Owens, EC Curtis, S Panda, R Santos-Oliveira, F Alexis, FM Kievit, DC Whitehead. Radiopaque Iodosilane-Coated Lipid Hybrid Nanoparticle Contrast Agent for Dual-Modality Ultrasound and X-ray Bioimaging. ACS Appl. Mater. Interfaces, 14 (49), 54389–54400, 2022.
    6. PA Chiarelli, RA Revia, ZR Stephen, K Wang, FM Kievit, J Sandhu, M Upreti, S Chung, RG Ellenbogen, M Zhang. Iron oxide nanoparticle-mediated radiation delivery for glioblastoma treatment. Materials Today, 56, 66-78, 2022.
    7. A Panagopoulos, S Samant, JJ Bakhos, M Liu, B Khan, J Makadia, F Muhammad, FM Kievit, DK Agrawal, YS Chatzizisis. Triggering receptor expressed on myeloid cells-1 (TREM-1) inhibition in atherosclerosis. Pharmacology & Therapeutics, 238, 2022.
    8. A Priester, R Waters, A Abbott, K Hilmas, K Woelk, HA Miller, AW Tarudji, CC Gee, B McDonald, FM Kievit, AJ Convertine. Theranostic Copolymers Neutralize Reactive Oxygen Species and Lipid Peroxidation Products for the Combined Treatment of Traumatic Brain Injury. Biomacromolecules, 23 (4) 1703–1712, 2022.
    9. HA Miller; FM Kievit. Theranostic Nanomaterials for Brain Injury, in Engineering Biomaterials for Neural Applications, 307-350, 2022.
    10. Bony BA; Tarudji AW; Miller HA; Gowrikumar S; Roy S; Curtis ET; Gee CC; Vecchio A; Dhawan P; Kievit FM. Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood–Brain Barrier. ACS Nano, 15 (11) 18520-18531, 2021.
    11. Miller HA; Schake MA; Bony BA; Curtis ET; Gee CC; McCue IS; Ripperda TJ; Chatzizisis YS; Kievit FM*; Pedrigi RM*. Smooth muscle cells affect differential nanoparticle accumulation in disturbed blood flow-induced murine atherosclerosis. PLoS ONE, 16 (12) e0260606, 2021.*co-corresponding authors
    12. McDonald BZ; Gee CC; Kievit FM. The Nanotheranostic Researcher’s Guide for Use of Animal Models of Traumatic Brain Injury. Journal of Nanotheranostics, 2 (4) 224-268, 2021.
    13. Shi W, Dong P, Kuss MA, Gu L, Kievit F, Kim HJ, Duan B. Design and Evaluation of an In Vitro Mild Traumatic Brain Injury Modeling System Using 3D Printed Mini Impact Device on the 3D Cultured Human iPSC Derived Neural Progenitor Cells. Advanced Healthcare Materials, 10, 2100180, 2021.
    14. Tarudji AW; Gee CC; Romereim SM; Convertine AJ; Kievit FM. Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury. Biomaterials, 2021.
    15. Wang K; Kievit FM; Chiarelli PA; Stephen ZR; Silber JR; Ellenbogen RG; Zhang M. siRNA nanoparticle suppresses drug-resistant gene and prolongs survival in an orthotopic glioblastoma xenograft mouse model. Advanced Functional Materials, 2021.
    16. Bony BA, Miller HA, Tarudji AW, Gee CC, Sarella A, Nichols MG, and Kievit FM. Ultrasmall Mixed Eu–Gd Oxide Nanoparticles for Multimodal Fluorescence and Magnetic Resonance Imaging of Passive Accumulation and Retention in TBI. ACS Omega, 2020.
    17. Tarudji AW; Kievit FM. Active targeting and transport. In: Nanoparticles for Biomedical Applications, Chung EJ, Leon L, Rinaldi C, editors. Elsevier, 2020, 19-36.
    18. Miller HA; Magsam AW; Tarudji AW; Romanova S; Weber L; Gee CC; Madsen GL; Bronich TK; Kievit FM. Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via K trans mapping with MRI. Scientific Reports 2019, 9, 1-14.
    19. Bony BA; Kievit FM. A Role for Nanoparticles in Treating Traumatic Brain Injury. Pharmaceutics 2019, 11, 473.
    20. Stephen ZR; Chiarelli PA; Revia RA; Wang K; Kievit FM; Dayringer CJ; Jeon M; Ellenbogen RG; Zhang M. Time-Resolved MRI Assessment of Convection-Enhanced Delivery by Targeted and Nontargeted Nanoparticles in a Human Glioblastoma Mouse Model. Cancer Research 2019, 79, 4776-86.
    21. Yoo D; Magsam AW; Kelly AM; Stayton PS; Kievit FM*; Convertine AJ*. Core crosslinked nanoparticles reduce neuroinflammation and improve outcome in a mouse model of traumatic brain injury. ACS Nano 2017, 11, 8600-11. *co-senior authors
    22. Chiarelli PA, Revia RA, Stephen ZR, Wang K, Jeon M, Nelson V, Kievit FM, Sham J, Ellenbogen RG, Kiem HP, Zhang M. Nanoparticle Biokinetics in Mice and Nonhuman Primates. ACS Nano 2017, 11, 9514-24.
    23. Kievit FM; Wang K; Ozawa T; Tarudji AW; Silber JR; Holland EC; Ellenbogen RG; Zhang M. Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma. Nanomedicine: NBM 2017, 13, 2131-9.
    24. Xu J, Ypma M, Chiarelli PA, Park J, Ellenbogen RG, Stayton PS, Mourad PD, Lee D, Convertine AJ*, Kievit FM*. Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury. Adv Funct Mater. 2016, 26, 4124-33. *co-senior authors
    25. Florczyk SJ*, Kievit FM*, Wang K, Erickson AE, Ellenbogen RG, Zhang M. 3D porous chitosan–alginate scaffolds promote proliferation and enrichment of cancer stem-like cells. J Mater Chem B 2016, 4, 6326-34. *co-first authors.
    26. Wang K, Kievit FM, Sham JG, Jeon M, Stephen ZR, Bakthavatsalam A, Park JO, Zhang M. Iron oxide-based nanovector for tumor targeted siRNA delivery in an orthotopic hepatocellular carcinoma xenograft mouse model. Small. 2016, 12, 477-87.
    27. Wang K, Kievit FM, Zhang M. Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies. Pharmacological Research 2016, 114, 56-6.
    28. Wang K, Kievit FM, Erickson AE, Ellenbogen RG, Zhang M. Culture on 3D Chitosan‐Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells. Adv Healthcare Mater 2016, 5, 3173-81.
    29. Kievit FM, Wang K, Erickson AE, Lan Levengood SK, Ellenbogen RG, Zhang M. Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells. Biomaterials Science. 2016, 4, 610-3.
    30. Wang K, Kievit FM, Jeon M, Silber JR, Ellenbogen RG, Zhang M. Nanoparticle-mediated target delivery of TRAIL as gene therapy for glioblastoma. Adv Healthcare Mater. 2015, 4, 2719-26.
    31. Mu Q, Kievit FM, Kant RJ, Lin G, Jeon M, Zhang M. Anti-HER2/neu peptide-conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells. Nanoscale 2015, 7, 6674-82.
    32. Wang K, Kievit FM, Florczyk SJ, Stephen ZR, Zhang M. 3D Porous Chitosan–Alginate Scaffolds as an In Vitro Model for Evaluating Nanoparticle–Mediated Tumor Targeting and Gene Delivery to Prostate Cancer. Biomacromolecules. 2015, 16, 3362-72. 
    33. Kievit FM, Stephen ZR, Wang K, Dayringer CJ, Sham JG, Ellenbogen RG, Silber JR, Zhang M. Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation. Molecular Oncology. 2015, 9, 1071-80.
    34. Fang C, Wang K, Stephen ZR, Mu Q, Kievit FM, Chiu DT, Press OW, Zhang M. Temozolomide Nanoparticles for Targeted Glioblastoma Therapy. ACS Applied Materials & Interfaces. 2015, 7, 6674-82.
    35. Chiarelli PA, Kievit FM, Zhang M, Ellenbogen RG. Bionanotechnology and the future of glioma. Surgical Neurology International. 2015, 6, Suppl S1:45-58.
    36. Sham JG, Kievit FM, Grierson JR, Chiarelli PA, Miyaoka RS, Zhang M, Yeung RS, Minoshima S, Park JO. Glypican-3 Targeting F(ab’)2 for 89Zr-PET of Hepatocellular Carcinoma. Journal of Nuclear Medicine. 2014, 55, 2032-7.
    37. Stephen ZR, Kievit FM, Veiseh O, Chiarelli PA, Fang C, Wang K, Hatzinger SJ, Ellenbogen RG, Silber JR, Zhang M. Redox responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors. ACS Nano. 2014, 8, 10383-95.
    38. Kievit FM, Florczyk SJ, Leung MC, Wang K, Wu J, Silber JR, Ellenbogen RG, Lee JSH, Zhang M. Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials 35, 9137-43 doi:10.1016/j.biomaterials.2014.07.037 (2014).
    39. Tsao CT, Kievit FM, Ravanpay A, Erickson AE, Jensen MC, Ellenbogen RG, Zhang M. Thermoreversible Poly(ethylene glycol)-g-Chitosan Hydrogel as a Therapeutic T Lymphocyte Depot for Localized Glioblastoma Immunotherapy. Biomacromolecules. 2014, 15, 2656-62.
    40. Sham JG, Kievit FM, Grierson JR, Miyaoka RS, Yeh MM, Zhang M, Yeung RS, Minoshima S, Park JO. Glypican-3 Targeted 89Zirconium-PET Imaging of Hepatocellular Carcinoma. Journal of Nuclear Medicine. 2014, 55, 799-804.
    41. Tsao CT, Kievit FM, Wang K, Erickson AE, Ellenbogen RG, Zhang M. Chitosan-Based Thermoreversible Hydrogel as an in Vitro Tumor Microenvironment for Testing Breast Cancer Therapies. Mol Pharm. 2014, 11, 2134-42.
    42. Phan-Lai V, Kievit FM, Florczyk SJ, Wang K, Disis ML, Zhang M. CCL21 and IFNγ Recruit and Activate Tumor Specific T cells in 3D Scaffold Model of Breast Cancer.Anti-cancer Agents in Medicinal Chemistry. 2014, 14, 204-10.
    43. Kievit FM, Cooper A, Jana S, Leung MC, Wang K, Edmondson D, Wood DL, Lee JSH, Ellenbogen RG, Zhang M. Aligned Chitosan-Polycaprolactone Polyblend Nanofibers Promote the Migration of Glioblastoma Cells. Adv Healthcare Mater. 2013, 2, 1651-9.
    44. Veiseh O, Kievit FM, Liu V, Fang C, Stephen ZR, Ellenbogen RG, Zhang M. In vivo safety evaluation of polyarginine coated magnetic nanovectors. Mol Pharm. 2013, 10, 4099-106.
    45. Florczyk SJ, Wang K, Jana S, Wood DL, Sytsma SK, Sham JG, Kievit FM, Zhang M. Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM. Biomaterials. 2013, 34, 10143-50
    46. Wang T, Kievit FM, Veiseh O, Arami H, Stephen ZR, Fang C, Liu Y, Ellenbogen RG, Zhang M. Targeted cell uptake of a non-internalizing antibody through conjugation to iron oxide nanoparticles in primary central nervous system lymphoma. World Neurosurgery. 2013, 80, 134-41.
    47. Pan-Lai V, Florczyk SJ, Kievit FM, Wang K, Gad E, Disis ML, Zhang M. Three-Dimensional Scaffolds to Evaluate Tumor Associated Fibroblast-Mediated Suppression of Breast Tumor Specific T Cells. Biomacromolecules. 2013, 14, 1330-7.
    48. Fang C, Kievit FM, Veiseh O, Stephen ZR, Wang T, Lee D, Ellenbogen RG, Zhang M. Fabrication of magnetic nanoparticles with controllable drug loading and release through a simple assembly approach. J Control Release. 2012, 162, 233-41.
    49. Fang C, Kievit FM, Cho YC, Mok H, Press OW, Zhang M. Effect of cationic side-chains on intracellular delivery and cytotoxicity of pH sensitive polymer-doxorubicin nanocarriers. Nanoscale. 2012, 4, 7012-20.
    50. Florczyk SJ, Liu G, Kievit FM, Lewis AM, Wu JD, Zhang M. 3D porous chitosan-alginate scaffolds: New matrix for studying prostate cancer cell-lymphocyte interaction in vitro. Adv Healthcare Mater. 2012, 1, 590-9.
    51. Kievit FM, Stephen ZR, Veiseh O, Arami H, Wang T, Lai VP, Park JO, Ellenbogen RG, Disis ML, Zhang M. Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs. ACS Nano. 2012, 6, 2591-601.
    52. Kievit FM, Zhang M. Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy. Acc Chem Res. 2011, 44, 853-62.
    53. Kievit FM, Zhang M. Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery across Biological Barriers. Adv Mater. 2011, 23, H217–H247.cover
    54. Veiseh O, Kievit FM, Ellenbogen RG, Zhang M. Cancer Cell Invasion: Treatment and Monitoring Opportunities in Nanomedicine. Adv Drug Deliv Rev. 2011, 63, 582-96.
    55. Veiseh O, Kievit FM, Mok H, Ayesh J, Clark C, Fang C, Leung M, Arami H, Park JO, Zhang M. Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery. Biomaterials. 2011, 32, 5717-25.
    56. Stephen ZR, Kievit FM, Zhang M. Magnetite nanoparticles for medical MR imaging.Materials Today. 2011, 14, 330-8.
    57. Cooper A, Bhattarai N, Kievit FM, Rossol M, Zhang M. Electrospinning of chitosan derivative nanofibers with structural stability in an aqueous environment. Phys Chem Chem Phys. 2011, 13, 9969-72.
    58. Kievit FM, Wang FY, Fang C, Mok H, Wang K, Silber JR, Ellenbogen RG, Zhang M. Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro J Control Release 2011, 152, 76-83.
    59. Park JO, Stephen Z, Sun C, Veiseh O, Kievit FM, Fang C, et al. Glypican-3 Targeting of Liver Cancer Cells Using Multifunctional Nanoparticles. Mol Imaging. 2010, 10, 69-77.
    60. Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behavior Nanomedicine (Lond)2010, 5, 1357-69.
    61. Mok H, Veiseh O, Fang C, Kievit FM, Wang FY, Park JO, Zhang M. pH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells Mol Pharm 2010, 7, 1930-9.
    62. Veiseh O, Kievit FM, Fang C, Mu N, Jana S, Leung MC, et al. Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery.Biomaterials. 2010;31(31):8032-42.
    63. Kievit FM, Veiseh O, Fang C, Bhattarai N, Lee D, Ellenbogen RG, et al. Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma. ACS Nano. 2010;4(8):4587-94.
    64. Leung M, Kievit FM, Florczyk SJ, Veiseh O, Wu J, Park JO, et al. Chitosan-alginate scaffold culture system for hepatocellular carcinoma increases malignancy and drug resistance. Pharm Res. 2010;27(9):1939-48.
    65. Kievit FM, Florczyk SJ, Leung MC, Veiseh O, Park JO, Disis ML, et al. Chitosan-alginate 3D scaffolds as a mimic of the glioma tumor microenvironment. Biomaterials. 2010;31(22):5903-10.
    66. Sun C, Du K, Fang C, Bhattarai N, Veiseh O, Kievit F, et al. PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano. 2010;4(4):2402-10.
    67. Veiseh O, Sun C, Fang C, Bhattarai N, Gunn J, Kievit F, et al. Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier. Cancer Res. 2009;69(15):6200-7.
    68. Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, et al. PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection. Adv Funct Mater. 2009;19(14):2244-51.
    69. Veiseh O, Gunn JW, Kievit FM, Sun C, Fang C, Lee JS, et al. Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles.Small.2009;5(2):256-64.
    70. Veiseh O, Kievit FM, Gunn JW, Ratner BD, Zhang M. A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells. Biomaterials. 2009;30(4):649-57.